The forbidden high ionisation line region of the type 2 quasar Q1131+16: a clear view of the inner face of the torus?

We present spectroscopic observations of the type 2 quasar SDSS J11311.05+162739.5 (Q1131+16 hereafter; z=0.1732), which has the richest spectrum of forbidden high ionisation lines (FHIL, e.g. [Fe \textsc{vii}], [Fe \textsc{x}], [Fe \textsc{xi}] and [Ne \textsc{v}]) yet reported for an AGN, as well as unusually strong [O \textsc{iii}]$\lambda$4363 emission. The study of this object provides a rare opportunity to investigate the physical conditions and kinematics of the region(s) emitting the FHILs. By comparison with photoionisation model results, we find that the FHIL region has high densities (10$^{5.5}$ $<$ $n_H$ $<10^{8.0}$ cm\textsuperscript{-3}) and ionisation parameters (-1.5 $<$ log[U] $<$ 0), yet its kinematics are similar to those of the low ionisation emission line region detected in the same object (FWHM $\sim$ 360$\pm$30 km/s), with no evidence for a significant shift between the velocity centroid of the FHILs and the rest frame of the host galaxy. The deduced physical conditions lie between those of the Broad-Line (n$_H$$>10^9$ cm\textsuperscript{-3}) and Narrow-Line Regions ($n_H$$<10^6$ cm\textsuperscript{-3}) of active galactic nuclei (AGN), and we demonstrate that the FHIL regions must be situated relatively close to the illuminating AGN (0.32 $<$ $r_{FHIL}$ $<$ 50pc). We suggest that the inner torus wall is the most likely location for the FHIL region, and that the unusual strength of the FHILs in this object is due to a specific viewing angle of the far wall of the torus, coupled with a lack of dust on larger scales that might otherwise obscure our view of the torus.Comment: Accepted for publication in the Monthly Notices of the Royal Astronomical Society (3rd of March 2011). 23 Pages (including tables 5 and 6 in the source file), 21 figure

A Model for Type 2 Coronal Line Forest (CLiF) AGNs

We present a model for the classification of Coronal Line Forest Active Galactic Nuclei (CLiF AGNs). CLiF AGNs are of special interest due to their remarkably large number of emission lines, especially forbidden highionization lines (FHILs). Rose et al. suggest that their emission is dominated by reflection from the inner wall of the obscuring region rather than direct emission from the accretion disk. This makes CLiF AGNs laboratories to test AGN-torus models. Modeling an AGN as an accreting supermassive black hole surrounded by a cylinder of dust and gas, we show a relationship between the viewing angle and the revealed area of the inner wall. From the revealed area, we can determine the amount of FHIL emission at various angles. We calculate the strength of [Fe VII]λ6087 emission for a number of intermediate angles (30°, 40°, and 50°) and compare the results with the luminosity of the observed emission line from six known CLiF AGNs. We find that there is good agreement between our model and the observational results. The model also enables us to determine the relationship between the type 2:type 1 AGN fraction vs the ratio of torus height to radius, h/r

Expert opinion in the management of aqueous Deficient Dry Eye Disease (DED) Cornea and external eye diseases

© 2015 Sy et al.Background: Dry eye disease (DED) affects millions of people worldwide. There are a variety of new treatments beyond traditional therapies such as preservative free artificial tears. Here, we conduct a survey to identify the most common tr

Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy.

Homeostatic maintenance of corneal endothelial cells is essential for maintenance of corneal deturgescence and transparency. In Fuchs endothelial corneal dystrophy (FECD), an accelerated loss and dysfunction of endothelial cells leads to progressively severe visual impairment. An abnormal accumulation of extracellular matrix (ECM) is a distinctive hallmark of the disease, however the molecular pathogenic mechanisms underlying this phenomenon are not fully understood. Here, we investigate genome-wide and sequence-specific DNA methylation changes of miRNA genes in corneal endothelial samples from FECD patients. We discover that miRNA gene promoters are frequent targets of aberrant DNA methylation in FECD. More specifically, miR-199B is extensively hypermethylated and its mature transcript miR-199b-5p was previously found to be almost completely silenced in FECD. Furthermore, we find that miR-199b-5p directly and negatively regulates Snai1 and ZEB1, two zinc finger transcription factors that lead to increased ECM deposition in FECD. Taken together, these findings suggest a novel epigenetic regulatory mechanism of matrix protein production by corneal endothelial cells in which miR-199B hypermethylation leads to miR-199b-5p downregulation and thereby the increased expression of its target genes, including Snai1 and ZEB1. Our results support miR-199b-5p as a potential therapeutic target to prevent or slow down the progression of FECD disease

Author Correction: Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy.

An amendment to this paper has been published and can be accessed via a link at the top of the paper

Training clinicians treating HIV to diagnose cytomegalovirus retinitis

© 2014, World Health Organization, All rights reserved.Problem Acquired immunodeficiency syndrome (AIDS)-related cytomegalovirus (CMV) retinitis continues to be a neglected source of blindness in resource-poor settings. The main issue is lack of capacity

Cross-Linking–Assisted Infection Reduction A Randomized Clinical Trial Evaluating the Effect of Adjuvant Cross-Linking on Outcomes in Fungal Keratitis

PurposeTo determine if there is a benefit to adjuvant corneal crosslinking (CXL) and to compare natamycin versus amphotericin B for filamentous fungal keratitis.DesignOutcome-masked, 2×2 factorial design, randomized controlled clinical trial.ParticipantsConsecutive patients presenting with moderate vision loss from a smear-positive fungal ulcer at Aravind Eye Hospital, Madurai, India.MethodsStudy eyes were randomized to 1 of 4 treatment combinations using an adaptive randomization protocol. The treatment arms included (1) topical natamycin 5% alone, (2) topical natamycin 5% plus CXL, (3) topical amphotericin B 0.15% alone, and (4) topical amphotericin 0.15% plus CXL.Main outcome measuresThe primary outcome of the trial was microbiological cure at 24 hours on repeat culture. Secondary outcomes included best spectacle-corrected visual acuity (BSCVA) at 3 weeks and 3 months, percentage of study participants with epithelial healing at 3 days, 3 weeks, and 3 months, infiltrate or scar size at 3 weeks and 3 months, 3-day smear and culture, and adverse events.ResultsThose randomized to CXL regardless of medication (topical natamycin or amphotericin) had 1.32-fold increased odds of 24-hour culture positivity, although this was not statistically significant (95% confidence interval [CI], 0.57-3.06; P&nbsp;= 0.51). We were also unable to find a difference in 24-hour culture positivity between those randomized to amphotericin and those randomized to natamycin when evaluating as a group regardless of whether or not they received CXL (coefficient 1.10; 95% CI, 0.47-2.54; P&nbsp;= 0.84). The BSCVA was approximately 0.22 logarithm of the minimum angle of resolution (logMAR) (2.2 Snellen lines) worse on average at 3 weeks among those receiving CXL regardless of medication (95% CI,&nbsp;-0.04 to 0.40; P&nbsp;= 0.04) and 0.32 logMAR (3.2 Snellen lines) worse visual acuity at 3 months after controlling for baseline visual acuity (95% CI, 0.03-0.54; P&nbsp;= 0.02). There was no difference in infiltrate or scar size, percentage of epithelialized or adverse events when comparing CXL with no CXL or the 2 topical medications.ConclusionsThere appears to be no benefit of adjuvant CXL in the primary treatment of moderate filamentous fungal ulcers, and it may result in decreased visual acuity